Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
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MA5-11945 targets Proteinase 3 in IF, FACS and WB applications and shows reactivity with mouse and human samples.
The MA5-11945 immunogen is hMC-1/PR3 cell granule extract.
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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