This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with bovine, canine, chimpanzee, equine, mouse, orangutan, rat and Rhesus monkey based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
PyK2, also known as protein tyrosine kinase, is known to be expressed in the central nervous system and from cells derived from hematopoietic lineages. In response to various stimuli that increase the intracellular calcium concentration, PyK2 gets rapidly phosphorylated on the tyrosine residues. On activation of the Pyk2 protein, the MAP kinase signaling pathway is activated and its activation brings about modulation of the ion channel function. The phosphorylation of tyrosin is brought about by reactions involving protein tyrosine phosphatases and the RAFT/Pyk2 kinase proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CADTK; CAK-beta; CAKB; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; FADK 2; FADK2; Focal Adhesion Kinase 2; Proline-rich tyrosine kinase 2; protein kinase B; Protein-tyrosine kinase 2-beta; PTK; PTK2B; PTK2B protein tyrosine kinase 2 beta; RAFTK; Related adhesion focal tyrosine kinase
Gene Aliases: CADTK; CAKB; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK
UniProt ID: (Human) Q14289
Entrez Gene ID: (Human) 2185