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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide made to a C-terminal region of the human Patched 1 protein (within residues 1200-1350).|
|Purification||Antigen affinity chromatography|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:250|
|Western Blot (WB)||1:2500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A Sonic Hedgehog receptor, Patched1 is a polytopic receptor protein that is essential for growth and differentiation. It has been implicated in making an impact in the variation in tumor and response to therapy in ovarian cancer. Patched1 activates Smoothened (SMO) constitutively in cells; in Gorlin syndrome patients, blocking this interaction is a very effective way to cease formation of basal cell neoplasia. In addition to its availability in cell membrane fractions, Patched1 C-terminal fragments also function as a signal transducer to the cell nucleus. In inflammatory processes like ischemia-reperfusion injury, Patched1 is upregulated and can be seen in histologically damaged areas. In the common pediatric tumor medulloblastoma, Patched1 is an indicator of susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BCNS; NBCCS; PTC; PTCH; 4; 5; HPE7; patched homolog 1; Protein patched homolog 1; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH protein -3; PTCH protein -3,4,5; PTCH11; RP11-435O5.3
BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH1; PTCH11