Bcr, receptor tyrosine kinase (also known as breakpoint cluster region or C-abl oncogene 1) is an intracellular protein belonging to the protein kinase superfamily and Tyr protein kinase family. It is a proto-oncogene with a SH2 domain, a SH3 domain and a protein kinase domain. Purified Bcr is known to contain autophosphorylation activity and transphosphorylation activity for several substrates. The function of this protein includes promoting the exchange of RAC or CDC42-bound GDP by GTP thereby activating them and hence acting as a GTPase activating protein. Moreover, PCAF and BCR signalling are essential for apoptotic cell death (PCAF and BCR signalling control cooperatively pre-mature B cell apoptosis via both depletions of DFFA and BIRC2). Ubiquitous expression of Bcr is seen in most tissues. Bcr with Abl1, in reciprocal translocation between chromosomes 22 and 9, produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia.
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Protein Aliases: ABL; bcr/abl; bcr/c-abl oncogene protein; BCR/FGFR1 chimera protein; breakpoint cluster region; Breakpoint cluster region protein; c-ABL; c-abl oncogene 1; FGFR1/BCR chimera protein; JTK7; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; receptor tyrosine kinase; Renal carcinoma antigen NY-REN-26; RP11-83J21.1; tyrosine-protein kinase ABL1; v-abl; v-abl Abelson murine leukemia viral oncogene homolog 1
Gene Aliases: ALL; BCR; BCR1; CML; D22S11; D22S662; PHL
UniProt ID: (Human) P78501
Entrez Gene ID: (Human) 613