FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.
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Protein Aliases: bacteria-expressed kinase; Basic fibroblast growth factor receptor 1; BEK fibroblast growth factor receptor; bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CD332; FGF Receptor 2; FGF receptor-1; fgfr 1; FGFR-1; FGFR-2; FGFR1/PLAG1 fusion; Fibroblast growth factor receptor 1; Fibroblast growth factor receptor 2; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; K-sam; Keratinocyte growth factor receptor; KGFR; MFR; N-sam; protein tyrosine kinase, receptor like 14; Proto-oncogene c-Fgr; Soluble KGFR
Gene Aliases: AU043015; AW208770; AW556123; BBDS; BEK; bFGF-R-1; BFGFR; BFR-1; c-fgr; CD331; CD332; CEK; CEK3; CFD1; Eask; ECCL; ECT1; FGFBR; FGFR-1; Fgfr-2; Fgfr-7; FGFR1; FGFR2; Fgfr7; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; Hspy; JWS; K-SAM; KAL2; KGFR; KGFRTr; KSAM; MFR; N-SAM; OGD; svs; TK14; TK25
Molecular Function: transmembrane signal receptor