This antibody is predicted to react with mouse and rat based on sequence homology.
PA5-12982 was used in western blot to show induction of phophorylation of GIT1 on Y554 in lysates of human umbilical vein endothelial cells.
GIT1 is a GTPase-activating protein for the ADP ribosylation factor family. It may serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. It increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia.
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Protein Aliases: ARF GAP GIT1; ARF GTPase-activating protein GIT1; CAT-1; CAT1; Cool-associated and tyrosine-phosphorylated protein 1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase interactor 1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1
Gene Aliases: GIT1
UniProt ID: (Human) Q9Y2X7
Entrez Gene ID: (Human) 28964