Positive Control: 293T
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Glycogen synthase kinase-3 beta (GSK3 beta) belongs to the subfamily of glycogen synthase kinases, that play a central role in energy metabolism, neuronal cell development, and body pattern formation. GSK3 has alpha and beta isoforms (51 kDa and 47 kDa respectively), that are functionally dissimilar. GSK3 beta plays a role in insulin and Wnt signaling, and is inhibited following the extracellular signaling events. GSK-3beta is a cytoplasmic serine/threonine protein kinase, which was initially identified as the kinase that phosphorylates glycogen synthase to inhibit glycogen synthesis. GSK3 beta is a ubiquitously expressed kinase that regulates a wide variety of cellular functions including metabolism, gene expression and cytoskeletal integrity. Akt/PI3K reduces GSK-3beta activity by phosphorylation of its Ser9 residue. GSK-3 beta has a critical role in the regulation of the amount of cyclin D1, as this kinase is involved in both cyclin D1 mRNA transcription and ubiquitin-dependent proteolysis. GSK3 beta is detected in testis, thymus, prostate and ovary, and weakly in lung, brain and kidney. GSK3 beta has been shown to be involved in protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; Serine/threonine-protein kinase GSK3B
Gene Aliases: GSK3B
UniProt ID: (Human) P49841
Entrez Gene ID: (Human) 2932