This antibody is predicted to react with human, mouse and non-human primate based on 100% sequence homology.
In Western blot, this antibody detects a ~100 kDa protein representing phospho-GluR1 (pSer845) in rat brain lysate. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AMPA-selective glutamate receptor 1; GluA1; GluR-1; GluR-A; GluR-K1; GluR1; GluRA; Glutamate Receptor 1; glutamate receptor A; Glutamate receptor ionotropic, AMPA 1; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA1 (alpha 1); GRIA1; HGBR1
Gene Aliases: GluA1; gluR-A; Glur1; Gria1
UniProt ID: (Rat) P19490
Entrez Gene ID: (Rat) 50592