Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Antibody detects endogenous levels of HMGCR only when phosphorylated at Ser872.
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; MGC103269
Gene Aliases: 3H3M; HMG-CoAR; HMGCR; LDLCQ3; Red
UniProt ID: (Human) P04035, (Mouse) Q01237, (Rat) P51639
Entrez Gene ID: (Human) 3156, (Mouse) 15357, (Rat) 25675
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