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MA1-24751 detects Histone H3 (phospho S28) from human, mouse, bovine, and hamster samples.
MA1-24751 has been successfully used in immunocytochemistry, flow cytometry and Western blot procedures. Western blot detects a band at ~15 kDa. A suggested positive control is whole extract of cultured human acute T cell leukemia Jurdat cells, treated with Nocodazole.
The MA1-24751 immunogen is a synthetic peptide, conjugated to KLH, corresponding to residues 23-35 of human Histone H3.
Store at 4ºC short term. For long term storage, store at -20ºC, avoiding freeze/thaw cycles.
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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