This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with Monkey, Bovine, Horse and Cat.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Insulin receptor substrate 1 (IRS1) is encoded by the IRS1 gene located on chromosome 2. IRS1 is a member of the IRS family of adaptor molecules along with IRS 2 and 3, which play a critical role in insulin signaling. Insulin binding to its cognate receptor is followed by autophosphorylation on tyrosine residues and activation of the Insulin Receptor (IR). IRS1 contains pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains at the N-terminus which directs IRS1 to IR. Phosphorylation of IRS1 on tyrosine residues is known to enhance insulin signaling while phosphorylation on Serine/Threonine residues can increase or decrease signaling. IRS1 interacts with PI3k and other signaling proteins such as Grb2 via the SRC homology domain (SH2 or SH3) for activation of both PI3k - Akt and MAP kinase signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Insulin receptor substrate 1; IRS-1
Gene Aliases: G972R; HIRS-1; IRS-1; IRS1