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PA1-26640 detects LAT (phospho Y132) from human samples. PA1-26640 is expected to cross react with mouse (85% conserved), rat (77% conserved) due to sequence homology.
PA1-26640 has been successfully used in Western blot procedures.
The PA1-26640 immunogen is a synthetic phosphopeptide corresponding to a portion of human LAT containing tyrosine 132.
LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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