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Invitrogen
Phospho-MAP2K4 (Thr261) Polyclonal Antibody
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Product Details
PA5-17878
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to residues around pThr261 of human SEK1
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10978887
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with the corresponding phosphorylated residues of MEK1, MEK2 or MKK3.
Target Information
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-JUN N-terminal kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 4; JNK kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK 1; MAP kinase kinase 4; MAP2K4delta; MAPK/ERK kinase 4; MAPKK 4; MEK 4; mitogen activated protein kinase kinase 4, variant 1; SAPK kinase 1; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; SEK1; Stress-activated protein kinase kinase 1
Gene Aliases: JNKK; JNKK1; MAP2K4; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1
UniProt ID: (Human) P45985, (Mouse) P47809
Entrez Gene ID: (Human) 6416, (Mouse) 26398, (Rat) 287398
protein kinase activity
receptor signaling protein serine/threonine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
nucleotide binding
protein serine/threonine kinase activity
MAP kinase kinase activity
JUN kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase kinase kinase binding
non-receptor serine/threonine protein kinase
apoptotic process
signal transduction
JNK cascade
response to wounding
peptidyl-tyrosine phosphorylation
proteolysis in other organism
Fc-epsilon receptor signaling pathway
cellular response to mechanical stimulus
negative regulation of motor neuron apoptotic process
MAPK cascade
positive regulation of protein phosphorylation
protein phosphorylation
activation of JUN kinase activity
phosphorylation
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of DNA replication
positive regulation of nitric-oxide synthase biosynthetic process
cell growth involved in cardiac muscle cell development
cellular response to sorbitol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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