This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.
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Protein Aliases: EC 18.104.22.168; kinase Syk; KSYK; p72-Syk; Spleen tyrosine kinase; SYK; Tyrosine-protein kinase SYK
Gene Aliases: p72-Syk; ptk72; SYK; Sykb