Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of tyrosine 791 (P-V-Y(p)-L-D) derived from Human Trk A.|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for IHC is human brain tissue.
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
EC 220.127.116.11; gp140trk; High affinity nerve growth factor receptor; High affinity nerve growth factor receptor precursor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; NTRK1; Oncogene TRK; p140-TrkA; TRK; Trk-A; TRK1 transforming tyrosine kinase protein; TRK1-transforming tyrosine kinase protein; TRKA; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A
MTC; NTRK1; p140-TrkA; TRK; Trk-A; TRK1; TRKA