Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.
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Protein Aliases: CD309; Embryonic receptor kinase 2; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); FLT; FLT-1; FMS-like tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); KDR; kinase insert domain protein receptor; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Kinase NYK; Protein-tyrosine kinase receptor flk-1; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 1; soluble VEGFR2; sVEGFR 1; tyrosine kinase growth factor receptor; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; Vascular permeability factor receptor; VEGF R1; VEGF receptor-2; VEGFR 1; VEGFR-1; VEGFR-2
Gene Aliases: 6130401C07; AI323757; CD309; Emrk2; Flk-1; FLK1; FLT; FLT-1; FLT1; FRT; KDR; Krd-1; Ly73; sFlt1; sVEGFR-2; VEGFR; VEGFR-1; VEGFR-2; VEGFR1; VEGFR2
Molecular Function: transmembrane signal receptor