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Western blot analysis of Phospho-beta-Catenin pSer552 in total cell lysates from SK-N-MC cells, treated with forskolin (FSK) for 30 minutes, or lysate treated with lambda phosphatase for 1 hour, using Phospho-beta-Catenin pSer552 polyclonal antibody (Product # PA5-17154) (upper) or a Beta-Catenin polyclonal antibody (bottom).
|Tested species reactivity||Chicken, Human, Mouse, Rat, Clawed frog, Zebrafish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide corresponding to residues surrounding pSer552 of human ß-catenin|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
It is not recommended to aliquot this antibody.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
beta-catenin; catenin (cadherin associated protein), beta 1, 88kDa; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta; catenin beta-1; OTTHUMP00000209289
armadillo; beta-catenin; Bfc; Catnb; CTNNB; CTNNB1; id:ibd2058; Mesc; MRD19; OK/SW-cl.35; PRO2286; wu:fb73e10; wu:fi81c06; wu:fk25h01