This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View Details
Antibodies to this protein (and modification) were previously sold as part of a Thermo Scientific Cellomics High Content Screening Kit. This replacement antibody is now recommended for researchers who need an antibody for high content cell based assays. It has been thoroughly tested and validated for cellular immunofluorescence (IF) applications. Further optimization including the selection of the most appropriate fluorescent Dylight conjugated secondary antibody may have to be performed for your high content assay.
It is not recommended to aliquot this antibody.
The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CRK1; CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug binding protein 1; Cytokine suppressive anti-inflammatory drug-binding protein; cytokine-supressive anti-inflammatory drug binding protein; EC 18.104.22.168; ERK1; etID18993.8; MAP 14; MAP kinase 14; MAP kinase 14A; MAP kinase 2; MAP kinase MXI2; MAP kinase p38; MAP kinase p38 alpha; MAP kinase p38a; MAP kinase p38alpha; MAPK 14; MAPK 14A; MAPK1 antibody; MAX-interacting protein 2; mitogen activated protein kinase 14; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase 14A; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase p38a; MK14; OTTHUMP00000216563; OTTHUMP00000216566; p38 alpha; p38 MAP kinase; p38 MAP kinase alpha; p38 MAPK; p38 mitogen activated protein kinase; p38alpha Exip; reactive kinase; RP1-179N16.5; SAPK2a; Stress-activated protein kinase 2a; tRNA synthetase cofactor p38
Gene Aliases: CRK1; CSBP; CSBP1; CSBP2; CSPB1; EXIP; fk28c03; hm:zeh1243; Hog; MAPK14; mapk14a; MXI2; p38; p38-alpha; p38a; p38ALPHA; p38Hog; p38MAPK; PRKM14; PRKM15; RK; SAPK2A; wu:fk28c03; zeh1243; zp38a