Product References
TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes.
Nature communications
Wetzel L,Blanchard S,Rama S,Beier V,Kaufmann A,Wollert T
700184 was used in Immunocytochemistry-immunoflourescence to find that LC3C cooperates with lysosomal TECPR1 to promote the degradation of disease-related protein aggregates in neural stem cells.
Fri Jun 12 00:00:00 EDT 2020
Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation.
Developmental cell
Nasr T,Mancini P,Rankin SA,Edwards NA,Agricola ZN,Kenny AP,Kinney JL,Daniels K,Vardanyan J,Han L,Trisno SL,Cha SW,Wells JM,Kofron MJ,Zorn AM
700184 was used in Immunohistochemistry to show that downstream of Gli the Foxf1+ splanchnic mesenchyme promotes medial constriction of the foregut at the boundary between the presumptive Sox2+ esophageal and Nkx2-1+ tracheal epithelium.
Mon Dec 16 00:00:00 EST 2019
Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation.
Developmental cell
Nasr T,Mancini P,Rankin SA,Edwards NA,Agricola ZN,Kenny AP,Kinney JL,Daniels K,Vardanyan J,Han L,Trisno SL,Cha SW,Wells JM,Kofron MJ,Zorn AM
700184 was used in Immunohistochemistry to show that downstream of Gli the Foxf1+ splanchnic mesenchyme promotes medial constriction of the foregut at the boundary between the presumptive Sox2+ esophageal and Nkx2-1+ tracheal epithelium.
Mon Dec 16 00:00:00 EST 2019
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis.
Nature communications
Serwas NK,Hoeger B,Ardy RC,Stulz SV,Sui Z,Memaran N,Meeths M,Krolo A,Yüce Petronczki Ö,Pfajfer L,Hou TZ,Halliday N,Santos-Valente E,Kalinichenko A,Kennedy A,Mace EM,Mukherjee M,Tesi B,Schrempf A,Pickl WF,Loizou JI,Kain R,Bidmon-Fliegenschnee B,Schickel JN,Glauzy S,Huemer J,Garncarz W,Salzer E,Pierides I,Bilic I,Thiel J,Priftakis P,Banerjee PP,Förster-Waldl E,Medgyesi D,Huber WD,Orange JS,Meffre E,Sansom DM,Bryceson YT,Altman A,Boztug K
700184 was used in Western Blotting to uncover DEF6 as player in immune homeostasis ensuring availability of the checkpoint protein CTLA-4 at T-cell surface, identifying a potential target for autoimmune and/or cancer therapy.
Mon Jul 15 00:00:00 EDT 2019
The extended cytoplasmic tail of the human B4GALNT2 is critical for its Golgi targeting and post-Golgi sorting.
The FEBS journal
Groux-Degroote S,Schulz C,Cogez V,Noël M,Portier L,Vicogne D,Solorzano C,Dall'Olio F,Steenackers A,Mortuaire M,Gonzalez-Pisfil M,Henry M,Foulquier F,Héliot L,Harduin-Lepers A
700184 was used in Immunocytochemistry-immunoflourescence to examine the subcellular distribution of the two B4GALNT2 protein isoforms in stably transfected colonic LS174T cells and in transiently transfected HeLa cells using fluorescence microscopy.
Sat Sep 01 00:00:00 EDT 2018
Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.
Nature communications
He K,Ma X,Xu T,Li Y,Hodge A,Zhang Q,Torline J,Huang Y,Zhao J,Ling K,Hu J
700184 was used in Immunocytochemistry-immunoflourescence to reveal that tubulin polyglutamylation is a major contributor for cilia signalling and suggest a potential therapeutic strategy to correct signalling defects in ciliopathies.
Fri Aug 17 00:00:00 EDT 2018
Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.
Nature communications
He K,Ma X,Xu T,Li Y,Hodge A,Zhang Q,Torline J,Huang Y,Zhao J,Ling K,Hu J
700184 was used in Immunocytochemistry-immunoflourescence to reveal that tubulin polyglutamylation is a major contributor for cilia signalling and suggest a potential therapeutic strategy to correct signalling defects in ciliopathies.
Fri Aug 17 00:00:00 EDT 2018
Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory.
eLife
Niu Y,Dai Z,Liu W,Zhang C,Yang Y,Guo Z,Li X,Xu C,Huang X,Wang Y,Shi YS,Liu JJ
700184 was used in immunohistochemistry to find that CNS-specific snx6-knockout mice exhibit deficits in spatial learning and memory, accompanied with loss of spines from distal dendrites of hippocampal CA1 pyramidal cells
Mon Jan 30 00:00:00 EST 2017
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Nature communications
Bartuzi P,Billadeau DD,Favier R,Rong S,Dekker D,Fedoseienko A,Fieten H,Wijers M,Levels JH,Huijkman N,Kloosterhuis N,van der Molen H,Brufau G,Groen AK,Elliott AM,Kuivenhoven JA,Plecko B,Grangl G,McGaughran J,Horton JD,Burstein E,Hofker MH,van de Sluis B
700184 was used in western blot to analyze how WASH- and CCC-mediated endosomal sorting of LDLr is needed for regular clearance of circulating LDL
Fri Mar 11 00:00:00 EST 2016
Exogenous α-synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ronzitti G,Bucci G,Emanuele M,Leo D,Sotnikova TD,Mus LV,Soubrane CH,Dallas ML,Thalhammer A,Cingolani LA,Mochida S,Gainetdinov RR,Stephens GJ,Chieregatti E
700184 was used in western blot to test if alpha-synuclein modulates neurotransmitter release
Wed Aug 06 00:00:00 EDT 2014
Exogenous α-synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ronzitti G,Bucci G,Emanuele M,Leo D,Sotnikova TD,Mus LV,Soubrane CH,Dallas ML,Thalhammer A,Cingolani LA,Mochida S,Gainetdinov RR,Stephens GJ,Chieregatti E
700184 was used in western blot to test if alpha-synuclein modulates neurotransmitter release
Wed Aug 06 00:00:00 EDT 2014