|Immunohistochemistry (Paraffin) (IHC (P))||1:200-1:1000|
|Western Blot (WB)||1:1000-1:4000|
|Tested Species reactivity||Hamster, Human, Non-human primate|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified, full-length, recombinant, human RNaseL produced in insect cells.|
|Contains||0.1% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody does not react with mouse or rat samples.
A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNase; interferon-induced 2-5A-dependent RNase; Ribonuclease 4; Ribonuclease L; ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent); ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RNase L
Gene Aliases: I79_009550; PRCA1; RNASEL; RNS4
UniProt ID: (Human) Q05823
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