MA5-15920 targets RSK2 in FACS, IF, and WB applications and shows reactivity with Human samples.
The MA5-15920 immunogen is purified recombinant fragment of human RSK2 expressed in E. Coli. .
MA5-15920 detects RSK2 which has a predicted molecular weight of approximately 80kDa.
RSK3 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in the gene have been associated with Coffin-Lowry syndrome (CLS).
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Protein Aliases: 90 kDa ribosomal protein S6 kinase 3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; p90-RSK 3; pp90RSK2; Ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 2; RSK-2; S6K-alpha-3
Gene Aliases: CLS; HU-3; ISPK-1; ISPK1; MAPKAPK1B; MRX19; p90-RSK2; pp90RSK2; RPS6KA3; RSK; RSK2; S6K-alpha3
UniProt ID: (Human) P51812
Entrez Gene ID: (Human) 6197
Molecular Function: annexin calcium-binding protein calmodulin intracellular calcium-sensing protein kinase non-receptor serine/threonine protein kinase protein kinase transfer/carrier protein transferase