This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA5-17169 targets RUNX3 in FACS, ICC, IHC, IF and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17169 immunogen is purified recombinant fragment of human RUNX3 (amino acids:186-252) expressed in E. Coli.
MA5-17169 detects RUNX3 which has a predicted molecular weight of approximately 44.4kDa.
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; CBF-alpha-3; core binding factor alpha 3; Core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; Oncogene AML-2; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2-alpha C; Polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 3; Runt-related transcription factor 3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2; transcription factor AML2/CBFA3
Gene Aliases: AML2; CBFA3; PEBP2A3; PEBP2aC; RUNX3
UniProt ID: (Human) Q13761