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Product Details
CF507036
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:4,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:150 | - |
Immunocytochemistry (ICC/IF) |
1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
OTI3G4 |
Immunogen |
Full length human recombinant protein of human SERPINB produced in HEK293T cell. |
Conjugate |
Unconjugated |
Form |
lyophilized |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 8% trehalose |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein T4-A; SCCA-1; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; Serpin B3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; spb3; Squamous cell carcinoma antigen 1
Gene Aliases: HsT1196; SCC; SCCA; SCCA-1; SCCA-PD; SCCA1; SERPINB3; SSCA1; T4-A
UniProt ID: (Human) P29508
Entrez Gene ID: (Human) 6317
Molecular Function:
protease inhibitor
positive regulation of cell proliferation
negative regulation of peptidase activity
positive regulation of epithelial to mesenchymal transition
positive regulation of endopeptidase activity
negative regulation of endopeptidase activity
positive regulation of cell migration
autocrine signaling
paracrine signaling
negative regulation of catalytic activity
negative regulation of JUN kinase activity
negative regulation of proteolysis
viral entry into host cell
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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