This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants.
Protein Aliases: GDN; Glia derived nexin; Glia-derived nexin; glial-derived neurite promoting factor; P17; Peptidase inhibitor 7; PI-7; PN-1; Protease nexin 1; Protease nexin I; Serpin E2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; SERPINE 2
Gene Aliases: GDN; GDNPF; PI-7; PI7; PN-1; PN1; PNI; SERPINE2
UniProt ID: (Human) P07093
Entrez Gene ID: (Human) 5270