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Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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HYB 245-01-02 is specific for human SP-D.
HYB 245-01-02 has been successfully used in Immunohistochemistry, ELISA and Western blot procedures. In immunohistochemical staining on paraffin embedded tissues, HYB 245-01 reacts specifically with SP-D.
Immunoreactivity can be found in epithelial cells of the lung, skin, small intestine, esophagus, gall-bladder, kidney and urinary bladder. In Western blotting after SDS-PAGE HYB 245-01 reacts strongly with SP-D, both in reduced and non-reduced forms. HYB 245-01 can be used for ELISA, but generally gives a weak signal.
The HYB 245-01-02 immunogen is recombinant neck CRD SP-D.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-A and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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