Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: SPDSGHPSSH NFSSGLSEHS EPSLSTEDSV LDAQRNTPTV LRPRDGSVDD RQSSEATTSQ DEAPREELAV QDSLESDLLA NESMDEFMSI TGSLDMALPE KDDVVMEGWR SSETEKHGQA DSEDNLSEEP EMESLFPALA SLAVTT
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.
Small G proteins such as RAP and RAB proteins are the key molecules in intracellular signal transduction and vesicle transportation. A novel protein family small G protein signaling modulator (SGSM) consisting of three members SGSM1-3 bind to RAP and RAB family proteins. All three SGSM proteins possess both a RUN domain and a TBC domain. SGSM1 (RUTBC2) is a 1, 148 amino acid protein that localizes to the Golgi apparatus and is mainly expressed in the CNS. SGSM1 interacts with RAP and RAB subfamily members of the small G proteins, and function as modulators of RAP and RAB-mediated neuronal signal transduction and vesicular transportation pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RUN and TBC1 domain containing 2; RUN and TBC1 domain-containing protein 2; Small G protein signaling modulator 1; small G protein signaling modulator 1 protein
Gene Aliases: KIAA1941; RUTBC2; SGSM1
UniProt ID: (Human) Q2NKQ1
Entrez Gene ID: (Human) 129049
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