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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 3 publications 3 publications |
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Published species |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
SIK1 Fusion Protein Ag3913 (423-769 aa encoded by BC038504) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.13 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: ASCSGVFRP RPVSPSSLLD TAISEEARQG PGLEEEQDTQ ESLPSSTGRR HTLAEVSTRL SPLTAPCIVV SPSTTASPAE GTSSDSCLTF SASKSPAGLS GTPATQGLLG ACSPVRLASP FLGSQSATPV LQAQGGLGGA VLLPVSFQEG RRASDTSLTQ GLKAFRQQLR KTTRTKGFLG LNKIKGLARQ VCQVPASRAS RGGLSPFHAP AQSPGLHGGA AGSREGWSLL EEVLEQQRLL QLQHHPAAAP GCSQAPQPAP APFVIAPCDG PGAAPLPSTL LTSGLPLLPP PLLQTGASPV ASAAQLLDTH LHIGTGPTAL PAVPPPRLAR LAPGCEPLGL LQGDCEM (423-769 aa encoded by BC038504 )
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HRT-20; Myocardial SNF1-like kinase; Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase); Salt-inducible kinase 1; salt-inducible protein kinase 1; serine/threonine protein kinase; Serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK; SIK-1; SNF1-like kinase
Gene Aliases: EIEE30; MSK; SIK; SIK1; SNF1LK
UniProt ID: (Human) P57059, (Mouse) Q60670
Entrez Gene ID: (Human) 150094, (Mouse) 17691
Molecular Function:
non-receptor serine/threonine protein kinase
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