This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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MA5-15677 targets SIRT1 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human and Non-human primate samples.
The MA5-15677 immunogen is purified recombinant fragment of human SIRT1 expressed in E. Coli.
MA5-15677 detects SIRT1 which has a predicted molecular weight of approximately 120kDa.
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 75SirT1; hSIR2; hSIRT1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2-like protein 1; SIRT 1; SIRT-1; SirtT1 75 kDa fragment; sirtuin type 1
Gene Aliases: SIR2; SIR2alpha; SIR2L1; SIRT1
UniProt ID: (Human) Q96EB6
Entrez Gene ID: (Human) 23411