This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA5-15677 targets SIRT1 in FACS, IF, IHC, and WB applications and shows reactivity with Human and Non-human primate samples.
The MA5-15677 immunogen is purified recombinant fragment of human SIRT1 expressed in E. Coli.
MA5-15677 detects SIRT1 which has a predicted molecular weight of approximately 120kDa.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
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Protein Aliases: hSIR2; hSIRT1; NAD-dependent protein deacetylase sirtuin-1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; SIR2L1; SIRT1; sirtuin type 1
Gene Aliases: SIR2; SIR2alpha; SIR2L1; SIRT1
UniProt ID: (Human) Q96EB6
Entrez Gene ID: (Human) 23411