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Invitrogen

SLC6A4 Recombinant Rabbit Monoclonal Antibody (16H2L7)

1 Published Figure
2 References
View all (27) SLC6A4 antibodies

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SLC6A4 Recombinant Rabbit Monoclonal Antibody (16H2L7)

Product Details

702076

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1-2 µg/mL
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

16H2L7

Immunogen

Peptides corresponding to Human SLC6A4 (aa 444-462, 16-29)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2633059

Product Specific Information

This antibody is predicted to react with Monkey, Horse and Cat

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; hSERT; Na+/Cl- dependent serotonin transporter; OTTHUMP00000163633; serotonin transporter; serotonin transporter 1; SERT; Sodium-dependent serotonin transporter; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 member 4; solute carrier family 6, member 4; unnamed protein product

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Gene Aliases: 5-HTT; 5-HTTLPR; 5HTT; AI323329; hSERT; HTT; OCD1; SERT; SERT1; SLC6A4

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UniProt ID: (Human) P31645, (Rat) P31652, (Mouse) Q60857

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Entrez Gene ID: (Human) 6532, (Rat) 25553, (Mouse) 15567

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Function(s)
integrin binding cation channel activity neurotransmitter transporter activity serotonin:sodium symporter activity protein binding monoamine transmembrane transporter activity antiporter activity syntaxin-1 binding cocaine binding sodium ion binding identical protein binding metal ion binding nitric-oxide synthase binding actin filament binding serotonin binding serotonin transmembrane transporter activity myosin binding Rab GTPase binding protein homodimerization activity neurotransmitter:sodium symporter activity symporter activity primary active transporter
Process(es)
response to hypoxia neurotransmitter transport serotonin transport amino acid transport response to nutrient memory circadian rhythm response to xenobiotic stimulus response to toxic substance positive regulation of gene expression positive regulation of serotonin secretion monoamine transport negative regulation of cerebellar granule cell precursor proliferation negative regulation of synaptic transmission, dopaminergic response to estradiol sodium ion transmembrane transport vasoconstriction negative regulation of neuron differentiation positive regulation of cell cycle negative regulation of organ growth behavioral response to cocaine enteric nervous system development brain morphogenesis serotonin uptake membrane depolarization male mating behavior platelet aggregation cellular response to retinoic acid cellular response to cGMP regulation of thalamus size neurotransmitter reuptake conditioned place preference brain development locomotory behavior response to organic substance thalamus development social behavior response to drug sperm ejaculation protein oligomerization protein homooligomerization transmembrane transport cellular response to organic substance transport organic cation transport ammonium transmembrane transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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