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Invitrogen

SLUG Monoclonal Antibody (OTI1A6)

View all (45) SLUG antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

MA5-26385

Applications Tested Dilution Publications

Western Blot (WB)

 1:1,000 -

Immunohistochemistry (Paraffin) (IHC (P))

 1:150 -

Flow Cytometry (Flow)

 1:100 -
Product Specifications

Species Reactivity

 Human

Host/Isotype

 Mouse / IgG1

Class

 Monoclonal

Type

 Antibody

Clone

 OTI1A6

Immunogen

Full length human recombinant protein of SNAI2 produced in E.coli
View immunogen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 1 mg/mL

Purification

 Affinity Chromatography

Storage buffer

 PBS, pH 7.3, with 1% BSA, 50% glycerol

Contains

 0.02% sodium azide

Storage conditions

 -20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2725366

Target Information

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; slug (chicken homolog), zinc finger protein; snail family zinc finger 2; snail homolog 2; Zinc finger protein SNAI2

Gene Aliases: SLUG; SLUGH; SLUGH1; SNAI2; SNAIL2; WS2D

UniProt ID: (Human) O43623

Entrez Gene ID: (Human) 6591

Molecular Function: C2H2 zinc finger transcription factor

Function(s)
negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation cell migration involved in endocardial cushion formation transcription, DNA-templated negative regulation of cell adhesion involved in substrate-bound cell migration Notch signaling pathway sensory perception of sound negative regulation of keratinocyte proliferation negative regulation of vitamin D biosynthetic process neural crest cell development positive regulation of cell migration negative regulation of chondrocyte differentiation regulation of chemokine production negative regulation of cell adhesion mediated by integrin positive regulation of histone acetylation negative regulation of catenin import into nucleus desmosome disassembly pigmentation negative regulation of DNA damage response, signal transduction by p53 class mediator cellular response to fibroblast growth factor stimulus positive regulation of fat cell differentiation regulation of osteoblast differentiation white fat cell differentiation palate development canonical Wnt signaling pathway epithelium development cartilage morphogenesis regulation of branching involved in salivary gland morphogenesis negative regulation of vitamin D receptor signaling pathway cellular response to epidermal growth factor stimulus cellular response to ionizing radiation negative regulation of canonical Wnt signaling pathway negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of stem cell proliferation regulation of bicellular tight junction assembly negative regulation of anoikis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Process(es)
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding sequence-specific DNA binding metal ion binding
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