Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-25448 detects SMARCA2 from human samples. PA1-25448 is expected to cross react with mouse (100% conserved), rat (100% conserved), Xenopus laevis (88% conserved), zebrafish (87% conserved), and chicken (94% conserved) due to sequence homology.
PA1-25448 has been successfully used in Western blot procedures.
The PA1-25448 immunogen is a synthetic peptide, conjugated to maleimide-activated KLH, corresponding to residues K(1354) E D V E K A K K R R G R P P A E(1370) of SMARCA2, with an N-terminal added cysteine.
SMARCA2 encodes a protein that is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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