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SMARCA2 encodes a protein that is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.
Protein Aliases: ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated factor 190B; FLJ36757; global transcription activator homologous sequence; hBRM; MGC74511; Probable global transcription activator SNF2L2; Protein brahma homolog; SNF2-alpha; SNF2/SWI2-like protein 2; sucrose nonfermenting 2-like protein 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
Gene Aliases: BAF190; BAF190B; BRM; hBRM; hSNF2a; NCBRS; SMARCA2; SNF2; SNF2A; SNF2L2; SNF2LA; Sth1p; SWI2
UniProt ID: (Human) P51531
Entrez Gene ID: (Human) 6595
Molecular Function: DNA helicase