AbboMax

SNAIL-1, 2, 3 Polyclonal Antibody

Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

630-740

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide SR AFA DRS NLR AHL QTH corresponding to human SNAI protein. It is identical to human, mice and rat.
View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

Positive control: HeLa whole cell lysate

Cellular location: Nucleus and cytoplasm.

Target Information

The Snail family of zinc-finger transcription factors consist of Snail1 (Snail), Snail2 (Slug) and Snail3 (Smuc), which shares an evolutionary conserved role in mesoderm formation in vertebrates. These molecules are composed of a highly conserved carboxy-terminal region containing four to six C2H2-type zinc fingers, which mediate sequence-specific interactions with DNA promoters containing an E-box sequence (CAGGTG). The amino termini of all vertebrate Snail family members contain the evolutionarily conserved SNAG (Snail/Gfi) domain, which is essential for transcriptional repression. Drosophila Snail lacks a SNAG domain; it has a consensus PxDLSx motif and exerts its repressive function through the interaction with the co-repressor CtBP. (PubMed: 20168078)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Neural crest transcription factor Slug; Protein sna; Protein snail homolog 1; Protein snail homolog 2; Protein snail homolog 3; slug (chicken homolog), zinc finger protein; Slug, chicken homolog; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family zinc finger 1; snail family zinc finger 2; snail family zinc finger 3; snail homolog 1; snail homolog 2; snail homolog 3; Snail-related gene from muscle cells; snail-related protein 2; Zinc finger protein 293; Zinc finger protein SNAI1; Zinc finger protein SNAI2; Zinc finger protein SNAI3

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Gene Aliases: AI194338; AI643946; dJ710H13.1; SLUG; SLUGH; SLUGH1; SLUGH2; SMUC; SNA; Sna1; SNAH; SNAI1; SNAI2; SNAI3; SNAIL; SNAIL1; SNAIL2; SNAIL3; WS2D; Zfp293; ZNF293

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UniProt ID: (Human) O95863, (Human) O43623, (Human) Q3KNW1, (Mouse) Q02085, (Rat) O08954, (Mouse) P97469, (Mouse) Q9QY31

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Entrez Gene ID: (Human) 6615, (Human) 6591, (Human) 333929, (Mouse) 20613, (Rat) 116490, (Rat) 25554, (Mouse) 20583, (Mouse) 30927, (Rat) 307919

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding protein binding kinase binding metal ion binding chromatin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding copper ion binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding molecular_function C2H2 zinc finger transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation mesoderm formation epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition negative regulation of vitamin D biosynthetic process cell migration positive regulation of cell migration hair follicle morphogenesis negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription, DNA-templated palate development cartilage morphogenesis trophoblast giant cell differentiation negative regulation of cell differentiation involved in embryonic placenta development left/right pattern formation Notch signaling involved in heart development negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of bicellular tight junction assembly cell migration involved in endocardial cushion formation transcription, DNA-templated negative regulation of cell adhesion involved in substrate-bound cell migration Notch signaling pathway sensory perception of sound negative regulation of keratinocyte proliferation neural crest cell development negative regulation of chondrocyte differentiation regulation of chemokine production negative regulation of cell adhesion mediated by integrin positive regulation of histone acetylation negative regulation of catenin import into nucleus desmosome disassembly pigmentation cellular response to fibroblast growth factor stimulus positive regulation of fat cell differentiation regulation of osteoblast differentiation white fat cell differentiation canonical Wnt signaling pathway epithelium development regulation of branching involved in salivary gland morphogenesis negative regulation of vitamin D receptor signaling pathway cellular response to epidermal growth factor stimulus cellular response to ionizing radiation negative regulation of canonical Wnt signaling pathway negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter negative regulation of stem cell proliferation negative regulation of anoikis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development mesoderm development negative regulation of transcription, DNA-templated negative regulation of cell cycle response to radiation negative regulation of apoptotic process regulation of transcription, DNA-templated cellular response to platelet-derived growth factor stimulus regulation of apoptotic process wound healing, spreading of cells positive regulation of endothelial cell chemotaxis
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