FIGURE: 1 / 2
Positive control: HeLa whole cell lysate
Cellular location: Nucleus and cytoplasm.
The Snail family of zinc-finger transcription factors consist of Snail1 (Snail), Snail2 (Slug) and Snail3 (Smuc), which shares an evolutionary conserved role in mesoderm formation in vertebrates. These molecules are composed of a highly conserved carboxy-terminal region containing four to six C2H2-type zinc fingers, which mediate sequence-specific interactions with DNA promoters containing an E-box sequence (CAGGTG). The amino termini of all vertebrate Snail family members contain the evolutionarily conserved SNAG (Snail/Gfi) domain, which is essential for transcriptional repression. Drosophila Snail lacks a SNAG domain; it has a consensus PxDLSx motif and exerts its repressive function through the interaction with the co-repressor CtBP. (PubMed: 20168078)
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Protein Aliases: Neural crest transcription factor Slug; Protein sna; Protein snail homolog 1; Protein snail homolog 2; Protein snail homolog 3; slug (chicken homolog), zinc finger protein; Slug, chicken homolog; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family zinc finger 1; snail family zinc finger 2; snail family zinc finger 3; snail homolog 1; snail homolog 2; snail homolog 3; Snail-related gene from muscle cells; snail-related protein 2; Zinc finger protein 293; Zinc finger protein SNAI1; Zinc finger protein SNAI2; Zinc finger protein SNAI3
Gene Aliases: AI194338; AI643946; dJ710H13.1; SLUG; SLUGH; SLUGH1; SLUGH2; SMUC; SNA; Sna1; SNAH; SNAI1; SNAI2; SNAI3; SNAIL; SNAIL1; SNAIL2; SNAIL3; WS2D; Zfp293; ZNF293
Molecular Function: C2H2 zinc finger transcription factor