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AbboMax

SNAIL-1, 2, 3 Polyclonal Antibody

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SNAIL-1, 2, 3 Polyclonal Antibody

Product Details

630-740

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide SR AFA DRS NLR AHL QTH corresponding to human SNAI protein. It is identical to human, mice and rat.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: HeLa whole cell lysate

Cellular location: Nucleus and cytoplasm.

Target Information

The Snail family of zinc-finger transcription factors consist of Snail1 (Snail), Snail2 (Slug) and Snail3 (Smuc), which shares an evolutionary conserved role in mesoderm formation in vertebrates. These molecules are composed of a highly conserved carboxy-terminal region containing four to six C2H2-type zinc fingers, which mediate sequence-specific interactions with DNA promoters containing an E-box sequence (CAGGTG). The amino termini of all vertebrate Snail family members contain the evolutionarily conserved SNAG (Snail/Gfi) domain, which is essential for transcriptional repression. Drosophila Snail lacks a SNAG domain; it has a consensus PxDLSx motif and exerts its repressive function through the interaction with the co-repressor CtBP. (PubMed: 20168078)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: mSNR2; neural crest transcription factor SLUG; protein sna; protein snail homolog 1; protein snail homolog 2; protein snail homolog 3; similar to chicken Slug; similar to Mus musculus zinc finger protein Sna and to Drosophila melanogaster snail protein; slug (chicken homolog), zinc finger protein; Slug, chicken homolog; sna; Snai1; snail 1 homolog; snail 1 zinc finger protein; snail family zinc finger 1; snail family zinc finger 2; snail family zinc finger 3; snail homolog 1; snail homolog 2; snail homolog 3; snail-related gene from muscle cells; snail-related protein 2; unnamed protein product; zinc finger protein 293; zinc-finger protein

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Gene Aliases: dJ710H13.1; SLUG; SLUGH; SLUGH1; SLUGH2; SMUC; SNA; Sna1; SNAH; SNAIL; SNAIL1; SNAIL2; SNAIL3; WS2D; Zfp293; ZNF293

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UniProt ID: (Human) O95863, (Human) O43623, (Human) Q3KNW1, (Mouse) Q02085, (Rat) O08954, (Mouse) P97469, (Mouse) Q9QY31

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Entrez Gene ID: (Human) 6615, (Human) 6591, (Human) 333929, (Mouse) 20613, (Rat) 116490, (Rat) 25554, (Mouse) 20583, (Mouse) 30927, (Rat) 307919

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding kinase binding sequence-specific DNA binding E-box binding sequence-specific double-stranded DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding copper ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter osteoblast differentiation epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation cell migration involved in endocardial cushion formation chromatin organization substrate-dependent cell migration negative regulation of cell adhesion involved in substrate-bound cell migration Notch signaling pathway sensory perception of sound response to radiation negative regulation of keratinocyte proliferation negative regulation of vitamin D biosynthetic process neural crest cell development cell migration positive regulation of cell migration negative regulation of chondrocyte differentiation regulation of chemokine production negative regulation of cell adhesion mediated by integrin desmosome disassembly negative regulation of apoptotic process pigmentation negative regulation of DNA damage response, signal transduction by p53 class mediator cellular response to fibroblast growth factor stimulus positive regulation of fat cell differentiation regulation of osteoblast differentiation white fat cell differentiation palate development epithelium development cartilage morphogenesis regulation of branching involved in salivary gland morphogenesis negative regulation of vitamin D receptor signaling pathway cellular response to epidermal growth factor stimulus cellular response to ionizing radiation negative regulation of canonical Wnt signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of stem cell proliferation regulation of bicellular tight junction assembly negative regulation of anoikis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand aortic valve morphogenesis mesenchymal cell differentiation mesoderm formation mesoderm development positive regulation of epithelial to mesenchymal transition hair follicle morphogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated canonical Wnt signaling pathway trophoblast giant cell differentiation negative regulation of cell differentiation involved in embryonic placenta development left/right pattern formation heterochromatin organization cellular response to platelet-derived growth factor stimulus regulation of apoptotic process wound healing, spreading of cells positive regulation of endothelial cell chemotaxis
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