|Tested species reactivity||Virus|
|Published species reactivity||Virus|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||SV40 transformed mouse line B4|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
MA5-12458 targets SV40 Large T Antigen in IF, IP, and WB applications and shows reactivity with Virus samples.
The MA5-12458 immunogen is sV40 transformed mouse line B4.
The simian virus 40 large T antigen plays important role in SV40 transfection and transformation of the cells. It binds to Rb and p53 suppressor proteins leading to the inactivation of suppressor pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Tumour secreted grp170 chaperones full-length protein substrates and induces an adaptive anti-tumour immune response in vivo.
MA5-12458 was used in western blot to study the involvement of grp170 in tumorigenesis and anti-tumour immune response
|Arnouk H,Zynda ER,Wang XY,Hylander BL,Manjili MH,Repasky EA,Subjeck JR,Latif Kazim A||International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (26:366)||2010|