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Semaphorin 3A (SEMA3A) Antibody (ASR-051-200UL) in WB
Western blot analysis of human THP-1 acute monocytic leukemia cell lysate (lanes 1 and 3) and human MDA-231 breast adenocarcinoma cell lysate (lanes 2 and 4): - 1,2. Anti-Semaphorin 3A (SEMA3A) Antibody (#ASR-051), (1:400).3,4. Anti-Semaphorin 3A (SEMA3A) Antibody , preincubated with Semaphorin 3A/SEMA3A Blocking Peptide (#BLP-SR051).
Product Details
ASR-051-200UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KRDRKQRRQRPGH, corresponding to amino acid residues 728-740 of rat SEMA3A, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 1 X 25 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: collapsin 1; collapsin-1; MGC133243; Sema D; sema domain, immunoglobulin domain (Ig), short basic domain, sec; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; Sema III; Semaphorin 3a; semaphorin D; Semaphorin III; semaphorin L; Semaphorin-3A; Semaphorin-D
Gene Aliases: coll-1; COLL1; HH16; Hsema-I; Hsema-III; SEMA1; SEMA3A; SEMAD; SEMAIII; SEMAL; SemD
UniProt ID: (Human) Q14563, (Mouse) O08665, (Rat) Q63548
Entrez Gene ID: (Human) 10371, (Mouse) 20346, (Rat) 29751
neural crest cell migration
neuron migration
regulation of heart rate
apoptotic process
axon guidance
axonal fasciculation
negative regulation of epithelial cell migration
facial nerve structural organization
trigeminal nerve structural organization
nerve development
olfactory bulb development
branchiomotor neuron axon guidance
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
ventral trunk neural crest cell migration
sympathetic nervous system development
dendrite morphogenesis
regulation of axon extension involved in axon guidance
negative regulation of axon extension involved in axon guidance
axon extension involved in axon guidance
sensory system development
negative chemotaxis
axonogenesis involved in innervation
dichotomous subdivision of terminal units involved in salivary gland branching
sympathetic ganglion development
trigeminal ganglion development
semaphorin-plexin signaling pathway
sympathetic neuron projection extension
sympathetic neuron projection guidance
neural crest cell migration involved in autonomic nervous system development
semaphorin-plexin signaling pathway involved in neuron projection guidance
semaphorin-plexin signaling pathway involved in axon guidance
neural crest cell migration involved in sympathetic nervous system development
facioacoustic ganglion development
positive regulation of male gonad development
positive regulation of neuron migration
multicellular organism development
nervous system development
motor neuron axon guidance
cell differentiation
negative regulation of axon extension
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