|Immunohistochemistry (Paraffin) (IHC (P))||1:2500|
|Western Blot (WB)||1:4000-1:6000|
|Immunohistochemistry (IHC)||See 1 publications below|
|Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues Q(344) E A T R P A H R A A A N G L M Q T S K L(364) of human SSTR5.|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA3-112 detects the Somatostatin Receptor 5 in human samples.
PA3-112 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR5 transfected HEK-293 cells this antibody detects a ~54-63 kDa protein representing SSTR5.
The PA3-112 immunogen is a synthetic peptide corresponding to residues Q(344) E A T P P A H R A A A N G L M Q T S K L(364) of human SSTR5.
Somatostatin Receptor Type 5 (SSTR5) has been reported to be expressed in adrenal, aorta, brain, breast, eye, heart, pancreas, prostate, skeletal muscle, small intestine, and thyroid. ESTs have been isolated from cartilage libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: somatostatin receptor subtype 5; Somatostatin receptor type 5; SS-5-R; SS5-R; SS5R; SSTR5
Gene Aliases: Smstr5; SS-5-R; sst5; SSTR5
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