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NeoBiotechnologies
Spectrin Alpha 1 Monoclonal Antibody (SPTA1, 1832)
Product Details
6708-MSM2-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
SPTA1, 1832
Immunogen
Recombinant human SPTA fragment (around aa356-475)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Antibody is tested in direct ELISA (Use Ab at 2-4 µg/mL for coating.
Immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-I spectrin; elliptocytosis 2; Erythroid alpha-spectrin; mutant alpha spectrin; spectrin alpha chain, erythrocyte; Spectrin alpha chain, erythrocytic 1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Gene Aliases: EL2; HPP; HS3; SPH3; SPTA; SPTA1
UniProt ID: (Human) P02549
Entrez Gene ID: (Human) 6708
MAPK cascade
lymphocyte homeostasis
porphyrin-containing compound biosynthetic process
ER to Golgi vesicle-mediated transport
plasma membrane organization
actin filament organization
axon guidance
regulation of cell shape
hemopoiesis
positive regulation of protein binding
positive regulation of T cell proliferation
positive regulation of GTPase activity
actin filament capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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