|Tested species reactivity||Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues D(187) P S Q D S S M P Y A P Y V E P(202) of rat Synaptogyrin 1.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:250|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-1044 detects Synaptogyrin 1 in rat and mouse samples.
PA1-1044 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~25.5 kDa protein representing Synaptogyrin 1 in rat and mouse brain tissue samples.
The PA1-1044 immunogen is a synthetic peptide corresponding to residues D(187) P S Q D S S M P Y A P Y V E P(202) of rat Synaptogyrin 1. This sequence is conserved in mouse and human. The PA1-1044 immunizing peptide (Cat. # PEP-280) is available for use in neutralization and control experiments.
Synaptogyrins comprise a family of tyrosine-phosphorylated proteins with two neuronal (synaptogyrins 1 and 3) isoforms. Previous studies have indicated that synaptogyrins are involved in the regulation of neurotransmitter release.
Synaptogyrin 1 is an integral membrane protein ubiquitously expressed in the nervous system. Synaptogyrin has four transmembrane domains and an extended cytoplasmic tail but it is not glycosylated. Synaptogyrin 1 is a tyrosine-phosphorylated by c-src and possibly other tyrosine kinases. The function of Synaptogyrin 1 is not well understood, but it may be a useful marker for nerve terminals and diagnosing neuroendocrine tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.