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|Tested species reactivity||Porcine , Hamster , Human , Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Synaptic immunoprecipitate (crude) from human brain.|
|Storage buffer||HEPES, pH 7.5, with 100µg/ml BSA, 50% glycerol, 0.15M NaCl|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Syntaxin 1 is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells and thought to be implicated in the regulation of synaptic neurotransmitter release. Syntaxin 1 interacts with several other proteins important for synaptic function (SNAP 25, Munc 18). Syntaxin 1 is the main target of one of the Botulinum neurotoxins (BoNT/C1) which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex. Syntaxin 1 is an essential component of the neurotransmitter release machinery, and regulation of Syntaxin 1 expression levels is thought to contribute to the mechanism underlying learning and memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
STX1, SYN1A, P35-1, HPC-1
neuron-specific antigen HPC-1, syntaxin-1A, P35A, synaptotagmin-associated 35 kDa protein, syntaxin 1A (brain)-like, SAP, STX1, Synaptotagmin associated 35 kDa protein, syntaxin 1A