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The protein encoded by this gene belongs to the paraneoplastic antigen MA (PNMA) family, which shares homology with retroviral Gag proteins. The PNMA antigens are highly expressed in the brain and also in a range of tumors associated with serious neurological phenotypes. There are reports of the presence of a functional -1 ribosomal frameshift signal (consisting of a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shifted product has not been characterized. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Paraneoplastic antigen Ma3; paraneoplastic cancer-testis-brain antigen
Gene Aliases: MA3; MA5; PNMA3
UniProt ID: (Human) Q9UL41
Entrez Gene ID: (Human) 29944
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