OriGene

TAF1B Monoclonal Antibody (OTI2C11), TrueMAB™

View all (14) TAF1B antibodies

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Datasheet

Protocols

Questions & Answers

Tech Support

Product Image Gallery

TAF1B Antibody in Western Blot (WB) — HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TAF1B (RC202142, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TAF1B. Positive lysates LY417139 (100 µg) and LC417139 (20 µg) can be purchased separately from OriGene.

Product Details

TA808719

Applications	Tested Dilution	Publications
Western Blot (WB)	1:2,000	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Mouse / IgG1
Class	Monoclonal
Type	Antibody
Clone	OTI2C11
Immunogen	Human recombinant protein fragment corresponding to amino acids 1-208 of human TAF1B produced in E.coli. View immunogen
Conjugate	Unconjugated
Form	liquid
Concentration	1 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS with 1% BSA, 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles

Target Information

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: RNA polymerase I-specific TBP-associated factor 63 kDa; SL1, 63kD subunit; TAFI63; TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kD; TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa; TATA box binding protein associated factor 1B; TATA box-binding protein-associated factor 1B; TATA box-binding protein-associated factor RNA polymerase I subunit B; TATA-box binding protein associated factor, RNA polymerase I, B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B

Gene Aliases: MGC:9349; RAF1B; RAFI63; SL1; TAF1B; TAFI63

UniProt ID: (Human) Q53T94

Entrez Gene ID: (Human) 9014

Function(s)

RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript transcription, DNA-templated regulation of transcription, DNA-templated transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription positive regulation of gene expression, epigenetic

Process(es)

RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting transcription factor activity, sequence-specific DNA binding protein binding TBP-class protein binding metal ion binding