|Tested species reactivity||Bovine, Human, Marsupial, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (163 DYQTHFRLREAQGRSRA 179) of TAG/TIRAP3b protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||2-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
TAG/TIRAP3/TICAM2 is a member of the Toll/Interleukin 1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). It undergoes post-translational modifications such as myristoylation and phosphorylation. TAG is a homodimer interacting with TLR4, TICAM1, IRF3 and IRF7 in response to LPS activation. The LPS-TLR4 signaling cascade regulates the MYD88-independent pathway during innate immune response. It is also involved in IL-1 triggered NF-kappa-B activation. It physically binds TLR4 and TICAM1 to transmit LPS-TLR4 signal to TICAM. Expression of TIRAP3 appears to be essential for TLR4 signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.