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|Tested species reactivity||Cattle , Human , Marsupial , Mouse , Primate , Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (163 DYQTHFRLREAQGRSRA 179) of TAG/TIRAP3b protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||2-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
TAG/TIRAP3/TICAM2 is a member of the Toll/Interleukin 1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). It undergoes post-translational modifications such as myristoylation and phosphorylation. TAG is a homodimer interacting with TLR4, TICAM1, IRF3 and IRF7 in response to LPS activation. The LPS-TLR4 signaling cascade regulates the MYD88-independent pathway during innate immune response. It is also involved in IL-1 triggered NF-kappa-B activation. It physically binds TLR4 and TICAM1 to transmit LPS-TLR4 signal to TICAM. Expression of TIRAP3 appears to be essential for TLR4 signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
cytoplasmic adaptor; NF-kappa-B-activating protein 502; putative NF-kappa-B-activating protein 502; TIR domain-containing adapter molecule 2; TIR domain-containing adapter protein; TIRAP3; TIRP; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; toll-like receptor adaptor molecule 2; toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule
B430113A10; BOS_10068; MyD88-4; TICAM-2; TICAM2; TIRAP3; TIRP; TRAM; Trif