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TBX1 Antibody (PA5-26389) in ICC/IF
Immunocytochemistry analysis of TBX1 in A2058 cells. Samples were incubated with TBX1 polyclonal antibody (Product # PA5-26389) using a dilution of 1:25 for 1 h at 37°C followed by Alexa Fluor® 488 conjugated donkey anti-rabbit at a dilution of 1:400 for 50 min at 37°C. Cells were fixed with 4% PFA (20 min) and permeabilized with Triton X-100 (0.1%, 10 min). Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7 units/mL, 1 h at 37°C). Nuclei were counterstained with DAPI (blue) (10 µg/mL, 10 min). TBX1 i... View More
Product Details
PA5-26389
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 327-356 amino acids from the C-terminal region of human TBX1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2543889
Target Information
TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brachyury; T-box 1 transcription factor C; T-box protein 1; T-box transcription factor TBX1; Testis-specific T-box protein
Gene Aliases: CAFS; CATCH22; CTHM; DGCR; DGS; DORV; TBX1; TBX1C; TGA; VCF; VCFS
UniProt ID: (Human) O43435
Entrez Gene ID: (Human) 6899
angiogenesis
blood vessel development
cell fate specification
neural crest cell migration
positive regulation of protein phosphorylation
lymph vessel development
positive regulation of mesenchymal cell proliferation
heart morphogenesis
outflow tract septum morphogenesis
outflow tract morphogenesis
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
determination of left/right symmetry
pattern specification process
mesoderm development
heart development
muscle organ development
sensory perception of sound
cell proliferation
positive regulation of cell proliferation
anterior/posterior pattern specification
vagus nerve morphogenesis
epithelial cell differentiation
thyroid gland development
social behavior
aorta morphogenesis
ear morphogenesis
inner ear morphogenesis
outer ear morphogenesis
middle ear morphogenesis
odontogenesis of dentin-containing tooth
muscle cell fate commitment
positive regulation of MAPK cascade
tongue morphogenesis
cellular response to fibroblast growth factor stimulus
negative regulation of cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
blood vessel morphogenesis
thymus development
muscle organ morphogenesis
embryonic cranial skeleton morphogenesis
embryonic viscerocranium morphogenesis
semicircular canal morphogenesis
artery morphogenesis
positive regulation of epithelial cell proliferation
parathyroid gland development
soft palate development
pharyngeal system development
face morphogenesis
muscle tissue morphogenesis
coronary artery morphogenesis
enamel mineralization
cellular response to retinoic acid
cochlea morphogenesis
mesenchymal cell apoptotic process
regulation of organ morphogenesis
positive regulation of tongue muscle cell differentiation
negative regulation of mesenchymal cell apoptotic process
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