Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
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Protein Aliases: Septin and tuftelin-interacting protein 1; STIP-1; Tuftelin-interacting protein 11
Gene Aliases: bK445C9.6; hNtr1; HSPC006; NTR1; Spp382; STIP; TFIP11; TIP39
UniProt ID: (Human) Q9UBB9
Entrez Gene ID: (Human) 24144