Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
MA1-91686 detects TGF alpha from human, mouse, rat, canine and hamster samples. MA1-91686 does not cross react with human or mouse EGF.
MA1-91686 has been successfully used in immunocytochemistry, immunohistochemistry (frozen tissue), immunohistochemistry (paraffin tissue) applications. MA1-91686 is not suitable for use in Western blot applications.
The MA1-91686 immunogen is: Recombinant full length protein (Human).
TGF-alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-alpha induces anchorage-independence transformation in cultured cells. Human, murine and rat TGF-alpha are cross-species reactive. TGFalpha (aa 50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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