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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant, full length human protein expressed in CHO cells.|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|ELISA (ELISA)||2 - 4 µg/ml|
|Inhibition Assays (IA)||0.3 - 1 µg/ml|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Blocking Assay (BLOCK)||See 2 publications below|
MA1-24734 detects TGF beta 1 from human samples.
MA1-24734 has been successfully used in inhibition assay, ELISA, and Western blot procedures. By ELISA, the antibody shows less than 5% cross-reactivity with TGF-beta 1.2 and less than 1% cross reactivity with TGF beta 2, TGF beta 3, and TGF beta 5.
The MA1-24734 immunogen is recombinant, full length human protein expressed in CHO cells.
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Transforming Growth Factor Beta 1 is a multifunctional peptide capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed as well as non-neoplastic tissues, release transforming growth factors; and essentially all cells possess a specific TGF beta 1 receptor. The multi-modal nature of TGF beta 1 is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta 1 whereas hepatocytes, T and B lymphocytes, keratinocytes and many epithelial cells are inhibited by the peptide. TGF beta 1 interacts with Epidermal Growth Factor, Platelet Derived Growth Factor, Fibroblast Growth Factor, and IL2 either by enhancing or antagonizing their characteristic actions. TGF beta 1 plays a fundamental role in tissue growth and differentiation involvement in adipogenesis, myogenesis, chondrogenesis, osteogenesis, epithelial cell differentiation and immune cell function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Ectopic expression of homeobox gene NKX2-1 in diffuse large B-cell lymphoma is mediated by aberrant chromatin modifications.
MA1-24734 was used in blocking or activating experiment to study the role of aberrant chromatin modifications in driving the ectopic expression of NKX2-1 in diffuse large B-cell lymphoma
|Nagel S,Ehrentraut S,Tomasch J,Quentmeier H,Meyer C,Kaufmann M,Drexler HG,MacLeod RA||PloS one (8:null)||2013|
Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors.
MA1-24734 was used in blocking or activating experiment to measure allogenic and auto-immune responses of human T cells in patients receiving pancreatic islet transplants
|Joffe M,Necula AS,Chand R,McWhinney BC,Krishnamurthy B,Loudovaris T,Goodman D,Thomas HE,Kay TW,Mannering SI||International immunology (24:447)||2012|
CED; DPD1; latency-associated peptide; prepro-transforming growth factor beta-1; TGF-beta-1; TGFB; TGFbeta
CED; DPD1; LAP; TGFB; TGFB1; TGFbeta