This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Protein Aliases: CDK105; Hairy cell leukemia protein 1; HCL G1; HUSSY29; L-name related protein; L-name-related protein 42; LNR42; NSA2; NSA2 ribosome biogenesis homolog; Ribosome biogenesis protein NSA2 homolog; TGF beta-inducible nuclear protein; TGF beta-inducible nuclear protein 1; TGF-beta inducible nuclear protein; TGF-beta-inducible nuclear protein 1; TINP1; YR 29
Gene Aliases: 5730427N09Rik; CDK105; HCL-G1; HCLG1; HUSSY-29; HUSSY29; LNR42; NSA2; Nsa2p; TINP1; Yr29