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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant fragment corresponding to residues 1-274 of mouse Tollip.|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-25840 detects TOLLIP from human and mouse samples.
MA1-25840 has been successfully used in Western blot procedures.
The MA1-25840 immunogen is a recombinant fragment corresponding to residues 1-274 of mouse Tollip.
TOLLIP is a ubiquitin-binding protein that interacts with several components of the Toll-like receptor (TLR; see MIM 603030) signaling cascade. It is an essential regulator of inflammatory signaling and is involved in trafficking of interleukin-1 receptor (IL1R; MIM 147810) and turnover of IL1R-associated kinase (IRAK, or IRAK1; MIM 300283) (summary by Lo et al., 2009 [PubMed 19444506]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
adapter protein; FLJ33531; IL-1RAcPIP; toll-interacting protein
4930403G24Rik; 4931428G15Rik; IL-1RAcPIP; TOLLIP