|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human TR2 protein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 3 publications below|
MA5-13986 targets TR2/HVEM in FACS, and IF applications and shows reactivity with Human samples.
The MA5-13986 immunogen is recombinant human TR2 protein.
TNF receptor like-2 (TR2) (also known as herpesvirus entry mediator (HVEM)) is expressed in multiple human tissues and cell lines and shows a constitutive and relatively high expression in peripheral T and B lymphocytes, and monocytes. It is a member of TNF receptor family. TR2/HVEM is a receptor for herpes virus. It also acts as a receptor for LIGHT (also known as HVEM ligand), a member of TNF family. TR2 protein inhibits a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts.
MA5-13986 was used in flow cytometry to identify how tea polyphenols affect development of periodontal disease
|Hosokawa Y,Hosokawa I,Ozaki K,Nakanishi T,Nakae H,Matsuo T||Molecular nutrition and food research (54 Suppl 2:S151)||2010|
TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts.
MA5-13986 was used in flow cytometry to investigate the effect of the combination of TNFSF14 and IFN-gamma on CXCL10 and CXCL11 production
|Hosokawa Y,Hosokawa I,Ozaki K,Nakae H,Matsuo T||Molecular immunology (47:666)||2010|
The TNF superfamily member LIGHT contributes to survival and activation of synovial fibroblasts in rheumatoid arthritis.
MA5-13986 was used in flow cytometry to investigate the role of LIGHT gene in synovial fibroblast activation and survival in rheumatoid arthritis
|Pierer M,Brentano F,Rethage J,Wagner U,Hantzschel H,Gay RE,Gay S,Kyburz D||Rheumatology (Oxford, England) (46:1063)||2007|