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|Tested species reactivity||Human, Rat, Clawed frog|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Cytoskeletal protein talin, purified from chicken gizzard.|
|Contains||15mM sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||Assay dependent|
|Immunoprecipitation (IP)||Assay dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-20231 detects talin in rat, Xenopus laevis and human samples. Does not react with fish.
MA1-20231 has been successfully used in immunocytochemistry, immunofluorescence, immunoprecipitation and Western blot procedures.
The MA1-20231 immunogen is cytoskeletal protein talin, purified from chicken gizzard.
Store at 4°C short term. For extended storage, store at -20°C, avoiding freeze/thaw cycles.
Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ILWEQ; KIAA1027; talin-1; TLN; TLN1